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Electrophysiological Studies Cultured granule cells or isolated HEK 293 transfected cells were voltage-clamped at -50 mV in the whole-cell configuration using the patch clamp technique trding the 56 stage of an inverted microscope at room temperature.

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4 CHAPTER 4 General Otolaryngology 129 99mTcpertechnetate:trappedbyfollicularcells,doesnotmeasure uptake, low dose radiation, less expensive, image obtained in single visit within 30 minutes Interpretation and Management hypofunctioning(cold)noduleshavea520malignancyrate, consider lobectomy and isthmusectomy, decision of completion of thyroidectomy based on accuracy of pathology (may consider a frozen section) hyperfunctioning(hot)nodulesmaybeobserved,4malignancy rate Other Tests ScreeningThyroidFunctionTests:TSH,freeT4 Ultrasound:indicatedtodistinguishcysts,guideFNAs,andidentify nonpalpable lesions CTMRI:evaluatessubsternalgoiter,nodalinvolvement,airwayand vascular displacement, tumor invasion ChestX-ray:metastasiswork-up,trachealdisplacement Thyroid Cysts Pathophysiology:typicallyarisesfromdegeneratednodules,mayresult from cystic degeneration of malignancy SSx:smooth,roundmass Dx:FNA,ultrasound,CT Rx:mayobserveforregression,fineneedleaspiraterelievespainand acquires cells for cytology, may fogex lobectomy for recurrent cysts that are recalcitrant to drainage or bloody aspirates Euthyroid Goiter Diffuse Colloid Goiter (Adenomatous Goiter, Multinodular Colloid Goiter) morecommoninwomen Pathophysiology:iodinedeficiencyTSHhypersecretion stimulates chronic thyroid hyperplasia and involution multinodularity ToxicNodularGoiter:variationofdiffusecolloidgoiterinwhichone nodule is hyperfunctional resulting in hyperthyroidism Types 1.

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